Structural surfaceomics reveals an AML-specific conformation of integrin β2 as a CAR T cellular therapy target

Abstract excerpt

Abstract Safely expanding indications for cellular therapies has been challenging given a lack of highly cancer-specific surface markers. Here we explore the hypothesis that tumor cells express cancer-specific surface protein conformations that are invisible to standard target discovery pipelines evaluating gene or protein expression, and these conformations can be identified and immunotherapeutically targeted....

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