Article

Defining the cell surface proteomic landscape of multiple myeloma reveals immunotherapeutic strategies and biomarkers of drug resistance

2021-01-19

Abstract excerpt

<h4>ABSTRACT</h4> The myeloma cell surface proteome (“surfaceome”) not only determines tumor interaction with the microenvironment but serves as an emerging arena for therapeutic development. Here, we use glycoprotein capture proteomics to first define surface markers most-enriched on myeloma when compared to B-cell malignancy models, revealing unexpected biological signatures unique to malignant plasma cells. We...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 75989da6-010b-5419-ae33-70ff15fcb55b
DOI: 10.1101/2021.01.17.427038

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Defining the cell surface proteomic landscape of multiple myeloma reveals immunotherapeutic strategies and biomarkers of drug resistanceDOI 10.1101/2021.01.17.427038Read

Plasma membrane profiling of multiple myeloma and the identification of novel monoclonal antibody targetsSemantic proximity Read

Comprehensive Characterization of the Multiple Myeloma Immune Microenvironment Using Integrated scRNA-seq, CyTOF, and CITE-seq AnalysisSemantic proximity Read

The antigenic landscape of multiple myeloma: mass spectrometry (re)defines targets for T-cell–based immunotherapySemantic proximity Read

Single-Cell Discovery and Multiomic Characterization of Therapeutic Targets in Multiple MyelomaSemantic proximity Read

Mass Cytometry reveals unique phenotypic patterns associated with subclonal diversity and outcomes in multiple myelomaSemantic proximity Read

The proteogenomic landscape of multiple myeloma reveals insights into disease biology and therapeutic opportunitiesSemantic proximity Read

Genomic Basis of Multiple Myeloma Subtypes from the MMRF CoMMpass StudySemantic proximity Read

Longitudinal multi-omic profiling uncovers immune escape and predictors of response in multiple myelomaSemantic proximity Read

Comprehensive molecular profiling of multiple myeloma identifies refined copy number and expression subtypesSemantic proximity Read

A single-cell atlas characterizes dysregulation of the bone marrow immune microenvironment associated with outcomes in multiple myelomaSemantic proximity Read

Utilizing Genomics to Identify Novel Immunotherapeutic Targets in Multiple Myeloma High-Risk SubgroupsSemantic proximity Read

The Tao of myeloma.Semantic proximity Read