Article

Structural surfaceomics reveals an AML-specific conformation of Integrin-β2 as a CAR-T therapy target

2022-10-11

Abstract excerpt

<h4>ABSTRACT</h4> Safely expanding indications for cellular therapies has been challenging given a lack of highly cancer-specific surface markers. Here, we explore the hypothesis that tumor cells express cancer-specific surface protein conformations, invisible to standard target discovery pipelines evaluating gene or protein expression, that can be identified and immunotherapeutically targeted. We term this strat...

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Literature Corpus work: 001124e8-0aef-53d6-8697-3272cdd8971a
DOI: 10.1101/2022.10.10.511511

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