Article

Proximity-Informed Graph Learning Defines Spatial Protein Communities for Tumor-Associated Proximity Antigen Discovery

2026-02-16

Abstract excerpt

The spatial organization of membrane proteins is an underexplored dimension of cell-surface biology. Spatial proximity shapes cellular function and therapeutic targetability, yet efforts to identify tumor-associated antigens (TAAs) have largely focused on expression alone. Here, we developed an industrialized surface-protein proximity mapping workflow to interrogate TAAs within their membrane microenvironments. In...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ac879978-2c22-5d3e-833d-a9947ba3f7ab
DOI: 10.64898/2026.02.13.705629

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Proximity-Informed Graph Learning Defines Spatial Protein Communities for Tumor-Associated Proximity Antigen DiscoveryDOI 10.64898/2026.02.13.705629Read

Mapping the nanoscale organization of the human cell surface proteome reveals new functional associations and surface antigen clustersSemantic proximity Read

Single-Cell Protein Interactomes by the Proximity Network AssaySemantic proximity Read

Functional PD-1/PD-L1 engagement defines a spatial biomarker of immunotherapy responseSemantic proximity Read

SPACE-GM: geometric deep learning of disease-associated microenvironments from multiplex spatial protein profilesSemantic proximity Read

Spatial proximity of tumor-immune interactions predicts patient outcome in hepatocellular carcinomaSemantic proximity Read

Transcriptomic Mapping of Non-Small Cell Lung Cancer K-RAS p.G12C Mutated Tumors: Identification of Surfaceome Targets and Immunologic Correlates.Semantic proximity Read

Family-Wide Photoproximity Profiling of Integrin Protein Social Networks in CancerSemantic proximity Read

Proximity Labeling: Precise Proteomics Technology for Mapping Receptor Protein Neighborhoods at the Cancer Cell SurfaceSemantic proximity Read

The Target Atlas for Antibody-Drug Conjugates across Solid CancersSemantic proximity Read

Spatial mapping of proteins and their activity states in cancer models by multiplex in situ PLASemantic proximity Read

Spatial Proximity of Immune Cell Pairs to Cancer Cells in the Tumor Microenvironment as Biomarkers for Patient StratificationSemantic proximity Read

A Graph Neural Network Approach for Hierarchical Mapping of Breast Cancer Protein CommunitiesSemantic proximity Read