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Single-cell transcriptomic analysis of normal and pathological tissues from the same patient uncovers colon cancer progression

21 Mar 2023

Abstract excerpt

The aim of the present study was to elucidate the evolutionary trajectory of colon cells from normal colon mucosa, to adenoma, then to carcinoma in the same microenvironment. Normal colon, adenoma and carcinoma tissues from the same patient were analyzed by single-cell sequencing, which perfectly simulated the process of time-dependent colon cancer due to the same microenvironment. A total of 22 cell types were...

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PMID: 36944972
DOI: 10.1186/s13578-023-01002-w

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