Article

Cell-type specific allelic dampening of sex-linked genes in sex chromosome aneuploidy

2026-04-21

Abstract excerpt

Common sex chromosome aneuploidies (SCAs) often present with cognitive and cardiovascular dysfunction in humans. To address SCA effects on gene expression and DNA methylation in relevant cell types, we differentiated neural precursor cells (NPCs) and cardiomyocytes (CMs) from human induced pluripotent stem cells (hiPSCs) with different numbers of sex chromosomes, including isogenic and independent lines. As expect...

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Literature Corpus work: edb9a806-44f3-53c7-901b-e06cde729497
DOI: 10.64898/2026.04.16.719032

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