Article

Decreased Clock Gene Bmal1 Mediates Epileptogenesis via PCDH19 in Temporal Lobe Epilepsy

2020-12-28

Abstract excerpt

Clock genes not only regulate the circadian rhythm of physiological activities but also participate in the pathogenesis of many diseases. Previous studies have found the abnormal expression of clock genes in epilepsy. However, as the core clock gene, the molecular mechanism of Bmal1 in the epileptogenesis and seizures of temporal lobe epilepsy (TLE) is still unclear. To define the function of Bmal1, we firstly inv...

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Literature Corpus work: edb33980-b6ce-5f25-8a0f-359b545271d4
DOI: 10.21203/rs.3.rs-133644/v1

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