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EPILEPTOGENESIS INHIBITS THE CIRCADIAN CLOCK AND RESHAPES THE DIURNAL TRANSCRIPTOMIC RHYTHMICITY IN THE MOUSE HIPPOCAMPUS

2024-07-04

Abstract excerpt

<h4>ABSTRACT</h4> Epileptogenesis is the process that leads the brain into epileptic activity. Clinical evidence shows that ∼90% of people with epilepsy present rhythmicity in the timing of their seizures presentation. However, whether the circadian clock is a key player during epileptogenesis remains unknown. Here, we triggered epileptogenesis in mice by the intra-amygdala injection of kainic acid and profiled b...

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Literature Corpus work
4b3c5e5c-fe43-5dd4-8083-4f1f7618c7d4
DOI
10.1101/2024.07.02.601732
Open publication

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EPILEPTOGENESIS INHIBITS THE CIRCADIAN CLOCK AND RESHAPES THE DIURNAL TRANSCRIPTOMIC RHYTHMICITY IN THE MOUSE HIPPOCAMPUSDOI 10.1101/2024.07.02.601732
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