Article

GABAergic signaling promotes early-life seizures in epileptic SYNGAP1 <sup>+/-</sup> mice

2020-11-15

Abstract excerpt

<h4>Objective</h4> SYNGAP1 encephalopathy is a developmental and epileptic encephalopathy caused by pathogenic loss of function variants. Syngap1 -heterozygous (Het +/- ) mice demonstrate progressive epilepsy with multiple seizure phenotypes in adulthood. Here, we investigate early-life seizures in Het +/- pups and explore of Syngap1 encephalopathy during development. <h4>Methods</h4> Post-natal day 7 (P7)...

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Literature Corpus work: 831a8af7-9a36-5ae1-b230-4767e6a23436
DOI: 10.1101/2020.11.14.381749

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