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Article

Critical Roles of the Circadian Transcription Factor BMAL1 in Reproductive Endocrinology and Fertility

2 Mar 2022

Abstract excerpt

Brain and muscle aryl-hydrocarbon receptor nuclear translocator like protein1 (BMAL1), a core component of circadian oscillation, is involved in many physiological activities. Increasing evidence has demonstrated the essential role of BMAL1 in reproductive physiology. For instance, BMAL1-knockout (KO) mice were infertile, with impaired reproductive organs and gametes. Additionally, in BMAL1-KO mice, hormone...

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Identifiers

PMID: 35311235
DOI: 10.3389/fendo.2022.818272

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