Article

Sterol derivative binding to the orthosteric site causes conformational changes in an invertebrate Cys-loop receptor

2023-01-06

Abstract excerpt

Cys-loop receptors or pentameric ligand-gated ion channels are mediators of electrochemical signaling throughout the animal kingdom. Because of their critical function in neurotransmission and high potential as drug targets, Cys-loop receptors from humans and closely related organisms have been thoroughly investigated, whereas molecular mechanisms of neurotransmission in invertebrates are less understood. When com...

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Literature Corpus work: edb2a619-ea33-55ca-a226-79efdef4549a
DOI: 10.1101/2023.01.06.523009

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