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Article

Positive modulation of a Cys-loop acetylcholine receptor by an auxiliary transmembrane subunit.

Nature neuroscience - 1 Oct 2012

Boulin Thomas, Rapti Georgia, Briseño-Roa Luis, Stigloher Christian, Richmond Janet E, Paoletti Pierre, Bessereau Jean-Louis

Abstract excerpt

Auxiliary subunits regulate the trafficking, localization or gating kinetics of voltage- and ligand-gated ion channels by associating tightly and specifically with pore-forming subunits. However, no auxiliary subunits have been identified for members of the Cys-loop receptor superfamily. Here we identify MOLO-1, a positive regulator of levamisole-sensitive acetylcholine receptors (L-AChRs) at the Caenorhabditis...

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Identifiers

PMID: 22922783
DOI: 10.1038/nn.3197

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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