Article

Trans-Lesion Synthesis and Mismatch Repair Pathway Crosstalk Defines Chemoresistance and Hypermutation Mechanisms in Glioblastoma

2023-10-19

Abstract excerpt

<h4>ABSTRACT</h4> Almost all Glioblastoma (GBM) are either intrinsically resistant to the chemotherapeutical drug temozolomide (TMZ) or acquire therapy-induced mutations that cause chemoresistance and recurrence. The genome maintenance mechanisms responsible for GBM chemoresistance and hypermutation are unknown. We show that the E3 ubiquitin ligase RAD18 (a proximal regulator of TLS) is activated in a Mismatch re...

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Literature Corpus work: 8672d2e2-8f10-578d-bedf-401e0c4a6fb0
DOI: 10.1101/2023.10.16.562506

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