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Trans-Lesion Synthesis and Mismatch Repair Pathway Crosstalk Defines Chemoresistance and Hypermutation Mechanisms in Glioblastoma

2023-10-16

Abstract excerpt

<title>Abstract</title> <p>Almost all Glioblastoma (GBM) are either intrinsically resistant to the chemotherapeutical drug temozolomide (TMZ) or acquire therapy-induced mutations that cause chemoresistance and recurrence. The genome maintenance mechanisms responsible for GBM chemoresistance and hypermutation are unknown. We show that the E3 ubiquitin ligase RAD18 (a proximal regulator of TLS) is activated in a Mi...

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Literature Corpus work
58dfb0c0-d744-5227-a23b-71a1d473af22
DOI
10.21203/rs.3.rs-2367368/v1
Open publication

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Trans-Lesion Synthesis and Mismatch Repair Pathway Crosstalk Defines Chemoresistance and Hypermutation Mechanisms in GlioblastomaDOI 10.21203/rs.3.rs-2367368/v1
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