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Article

Differential Roles of Rad18 and Chk2 in Genome Maintenance and Skin Carcinogenesis Following UV Exposure.

The Journal of investigative dermatology - 1 Dec 2018

Tanoue Yuki, Toyoda Takeshi, Sun Jinghua, Mustofa Md Kawsar, Tateishi Chie, Endo Shinya, Motoyama Noboru, Araki Kimi, Wu Di, Okuno Yutaka, Tsukamoto Tetsuya, Takeya Motohiro, Ihn Hironobu, Vaziri Cyrus, Tateishi Satoshi

Abstract excerpt

Defects in DNA polymerase Eta (Polη) cause the sunlight-sensitivity and skin cancer-propensity disorder xeroderma pigmentosum variant. The extent to which Polη function depends on the upstream E3 ubiquitin ligase Rad18 is controversial and has not been investigated using mouse models. Therefore, we tested the role of Rad18 in UV-inducible skin tumorigenesis. Because Rad18 deficiency leads to compensatory DNA...

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Identifiers

PMID: 29859927
DOI: 10.1016/j.jid.2018.05.015

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Differential Roles of Rad18 and Chk2 in Genome Maintenance and Skin Carcinogenesis Following UV Exposure.PMID 29859927Read ↗

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Pirh2 E3 Ubiquitin Ligase Targets DNA Polymerase Eta for 20S Proteasomal DegradationSemantic proximity Read ↗

Telomere Length and Telomerase Activity Impact the UV Sensitivity Syndrome Xeroderma Pigmentosum CSemantic proximity Read ↗

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