Article

Effect of Nrf2 Loss on Senescence and Cognition of Tau-Based P301S Mice

2022-11-01

Abstract excerpt

Cellular senescence may contribute to chronic inflammation involved in the progression of age-related diseases such as Alzheimer’s Disease (AD), and its removal prevents cognitive impairment in a model of tauopathy. Nrf2, the major transcription factor for damage response pathways and regulators of inflammation, declines with age. Our previous work showed that silencing Nrf2 gives rise to premature senescence in c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: edaaf97f-9189-56de-93cc-026df08a386f
DOI: 10.1101/2022.10.31.514571

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Effect of Nrf2 Loss on Senescence and Cognition of Tau-Based P301S MiceDOI 10.1101/2022.10.31.514571Read

Aging, NRF2, and TAU: A Perfect Match for Neurodegeneration?Semantic proximity Read

Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer’s diseaseSemantic proximity Read

Senescence Targeting Methods Impact Alzheimer’s Disease Features in 3xTg MiceSemantic proximity Read

Telomere-driven senescence accelerates tau pathology, neuroinflammation and neurodegeneration in a tauopathy mouse modelSemantic proximity Read

Pharmacological doses of melatonin impede cognitive decline in tau‐related Alzheimer models, once tauopathy is initiated, by restoring the autophagic fluxSemantic proximity Read

Senolytic Intervention Improves Cognition, Metabolism, and Adiposity in Female APP <sup>NL-F/NL-F</sup> MiceSemantic proximity Read

Resumption of Autophagy by Ubisol-Q10 in Presenilin-1 Mutated Fibroblasts and Transgenic AD Mice: Implications for Inhibition of Senescence and Neuroprotection.Semantic proximity Read

Telomere-induced senescence increases aberrant intraneuronal amyloid-β accumulation by impairing autophagy in a mouse model of Alzheimer’s diseaseSemantic proximity Read

Senolytic therapy preserves blood-brain barrier integrity and promotes microglia homeostasis in a tauopathy modelSemantic proximity Read

Acarbose improves cognitive function in a mouse model of normal aging but not Alzheimer’s diseaseSemantic proximity Read

A study to determine the effect of nano-selenium and thymoquinone on the Nrf2 gene expression in Alzheimer’s diseaseSemantic proximity Read

Small molecule cognitive enhancer reverses age-related memory decline in miceSemantic proximity Read