Article

Dynamics of local B cell migration during affinity maturation in the human tonsil

2025-11-03

Abstract excerpt

Affinity maturation enhances B cell binding within germinal centers, where spatial structure preserves sequence diversity by restricting cell movement. While recent studies show that some B cell lineages span multiple germinal centers, the sources, rates and consequences of this spreading process remain unknown. Here, we show that the spatial arrangement of B cells in the human tonsil is driven by local migration...

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Literature Corpus work: ed8584d7-1ec1-5355-9afc-b7e862f36eb9
DOI: 10.1101/2025.10.31.685876

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