Article

Convergent Evolution and B-Cell Recirculation in Germinal Centers in a Human Lymph Node

2022-11-10

Abstract excerpt

Germinal centers (GCs) are specialized compartments within the secondary lymphoid organs where B cells proliferate, differentiate, and mutate their antibody genes in response to the presence of foreign antigens. They play a central role in generating an effective immune response against infectious pathogens, and failures in their regulating mechanisms can lead to the development of autoimmune diseases and cancer....

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Literature Corpus work: 59e964ce-3b23-5118-af6e-aa0577770240
DOI: 10.1101/2022.11.09.463832

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