Article

Plakophilin-2 Coordinates Energy Metabolism and Contractility in Cardiomyocytes, Revealing Its Roles beyond Desmosomes

2025-01-20

Abstract excerpt

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a familial cardiac disease associated with ventricular arrhythmias and an increased risk of sudden cardiac death. Mutations in the desmosome gene Plakophilin-2 , PKP2 , lead to reduction in PKP2 protein and collapse of desmosomes that is known to compromise contractility and electrical stability of cardiomyocytes. Our previous studies demonstrated the eff...

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Literature Corpus work: ed71a59d-1d4f-59b6-bdb5-b561aa496e1e
DOI: 10.1101/2025.01.17.633239

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