Article

PKP2 orchestrates OXPHOS expression in cardiomyocytes via a PGC1α-dependent mechanism

2025-06-04

Abstract excerpt

<h4>ABSTRACT</h4> Arrhythmogenic cardiomyopathy (ACM) is an inherited cardiac disease where the majority of ACM patients carry a (likely) pathogenic variant in desmosomal genes, predominantly in plakophilin-2 ( PKP2 ). While the genetic cause of the disease is well studied, the molecular disease-driving mechanisms and how exercise can drive disease progression remain poorly understood. In this study, we identifi...

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Literature Corpus work: bdf744f5-bfd9-5c3e-b2cb-0a789b92ca71
DOI: 10.1101/2025.06.02.656790

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