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Article

Maturation-Based Model of Arrhythmogenic Right Ventricular Dysplasia Using Patient-Specific Induced Pluripotent Stem Cells.

Circulation journal : official journal of the Japanese Circulation Society - 1 Jan 2015

Wen Jian-Yan, Wei Chuan-Yu, Shah Khooshbu, Wong Johnson, Wang Cheng, Chen Huei-Sheng Vincent

Abstract excerpt

Cellular reprogramming of somatic cells to patient-specific induced pluripotent stem cells (iPSCs) enables in-vitro modeling of human cardiac disorders for pathogenic and therapeutic investigations. However, using iPSC-derived cardiomyocytes (iPSC-CMs) to model an adult-onset heart disease remains challenging because of the uncertainty regarding the ability of relatively immature iPSC-CMs to fully recapitulate...

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PMID: 25971409
DOI: 10.1253/circj.CJ-15-0363

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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