Article
Generation of patient-specific induced pluripotent stem cell-derived cardiomyocytes as a cellular model of arrhythmogenic right ventricular cardiomyopathy.
European heart journal - 1 Apr 2013
Ma Dongrui, Wei Heming, Lu Jun, Ho Shuswen, Zhang Guangqing, Sun Xiaoming, Oh Yingzi, Tan Suat Hoon, Ng Mah Lee, Shim Winston, Wong Philip, Liew Reginald
Abstract excerpt
AIMS: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a primary heart muscle disorder associated with sudden cardiac death. Its pathophysiology is still poorly understood. We aimed to produce an in vitro cellular model of ARVC using patient-specific induced pluripotent stem cell (iPSC)-derived cardiomyocytes and determine whether the model could recapitulate key features of the disease phenotype....
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