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Article

Modeling of arrhythmogenic right ventricular cardiomyopathy with human induced pluripotent stem cells.

Circulation. Cardiovascular genetics - 1 Dec 2013

Caspi Oren, Huber Irit, Gepstein Amira, Arbel Gil, Maizels Leonid, Boulos Monther, Gepstein Lior

Abstract excerpt

BACKGROUND: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a primary heart muscle disorder resulting from desmosomal protein mutations. ARVC is characterized pathologically by fibrofatty infiltration and clinically by arrhythmias and sudden cardiac death. We aimed to establish a patient-/disease-specific human induced pluripotent stem cell (hiPSC) model of ARVC. METHODS AND RESULTS: Dermal fibroblasts...

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Source

Identifiers

PMID: 24200905
DOI: 10.1161/CIRCGENETICS.113.000188

Genes

PKP2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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