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Therapeutic efficacy of AAV-mediated restoration of PKP2 in arrhythmogenic cardiomyopathy

7 Dec 2023

Abstract excerpt

Abstract Arrhythmogenic cardiomyopathy is a severe cardiac disorder characterized by lethal arrhythmias and sudden cardiac death, with currently no effective treatment. Plakophilin 2 ( PKP2 ) is the most frequently affected gene. Here we show that adeno-associated virus (AAV)-mediated delivery of PKP2 in PKP2 c.2013delC/WT induced pluripotent stem cell-derived cardiomyocytes restored not only cardiac PKP2 levels...

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PMID: 38665939
DOI: 10.1038/s44161-023-00378-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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