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Article

Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs.

Nature - 7 Feb 2013

Kim Changsung, Wong Johnson, Wen Jianyan, Wang Shirong, Wang Cheng, Spiering Sean, Kan Natalia G, Forcales Sonia, Puri Pier Lorenzo, Leone Teresa C, Marine Joseph E, Calkins Hugh, Kelly Daniel P, Judge Daniel P, Chen Huei-Sheng Vincent

Abstract excerpt

Cellular reprogramming of somatic cells to patient-specific induced pluripotent stem cells (iPSCs) enables in vitro modelling of human genetic disorders for pathogenic investigations and therapeutic screens. However, using iPSC-derived cardiomyocytes (iPSC-CMs) to model an adult-onset heart disease remains challenging owing to the uncertainty regarding the ability of relatively immature iPSC-CMs to fully...

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Identifiers

PMID: 23354045
DOI: 10.1038/nature11799
PMCID: PMC3753229

Genes

PKP2

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