Role of plakophilin-2 expression on exercise-related progression of arrhythmogenic right ventricular cardiomyopathy: a translational study.

doi:10.1093/eurheartj/ehab772

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Article

Role of plakophilin-2 expression on exercise-related progression of arrhythmogenic right ventricular cardiomyopathy: a translational study.

European heart journal - 21 Mar 2022

Cerrone Marina, Marrón-Liñares Grecia M, van Opbergen Chantal J M, Costa Sarah, Bourfiss Mimount, Pérez-Hernández Marta, Schlamp Florencia, Sanchis-Gomar Fabian, Malkani Kabir, Drenkova Kamelia, Zhang Mingliang, Lin Xianming, Heguy Adriana, Velthuis Birgitta K, Prakken Niek H J, LaGerche Andre, Calkins Hugh, James Cynthia A, Te Riele Anneline S J M, Delmar Mario

Abstract excerpt

AIMS: Exercise increases arrhythmia risk and cardiomyopathy progression in arrhythmogenic right ventricular cardiomyopathy (ARVC) patients, but the mechanisms remain unknown. We investigated transcriptomic changes caused by endurance training in mice deficient in plakophilin-2 (PKP2cKO), a desmosomal protein important for intercalated disc formation, commonly mutated in ARVC and controls. METHODS AND RESULTS:...

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Identifiers

PMID: 34932122
DOI: 10.1093/eurheartj/ehab772
PMCID: PMC8934688

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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