Article

Therapeutic modulation of the blood-brain barrier and ischemic stroke by a bioengineered FZD <sub>4</sub> -selective WNT surrogate

2022-10-14

Abstract excerpt

Derangements of the blood-brain barrier (BBB) or blood-retinal barrier (BRB) occur in disorders ranging from stroke, cancer, diabetic retinopathy, and Alzheimer’s disease. The Norrin/FZD 4 /TSPAN12 pathway activates WNT/β-catenin signaling, which is essential for BBB and BRB function. However, systemic pharmacologic FZD 4 stimulation is hindered by obligate palmitoylation and insolubility of native WNTs and subo...

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Literature Corpus work: ed61e7d0-a333-5195-ad10-62f1ad9a8011
DOI: 10.1101/2022.10.13.510564

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