Article

Development of Norrin-Based Protein Therapeutic for Activation of Norrin-Wnt Signaling in Human Retinal Endothelial Cells

2025-10-17

Abstract excerpt

Norrin-Wnt signaling is essential for retinal vascular development and generation of the inner blood retinal barrier. Norrin itself is a potential therapeutic for retinal vascular repair. We explored the feasibility of producing a recombinant protein therapeutic based on human Norrin for intravitreal injection. NorrinK86P production was testing using MBP-fusion and non-tagged versions. FZD4 binding was evaluated b...

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Literature Corpus work: 8226311f-3db3-5961-81de-009a879b8e4d
DOI: 10.20944/preprints202510.1336.v1

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