Article
TrkAIII. A novel hypoxia-regulated alternative TrkA splice variant of potential physiological and pathological importance.
Cell cycle (Georgetown, Tex.) - 1 Jan 2005
Tacconelli Antonella, Farina Antonietta R, Cappabianca Lucia, Gulino Alberto, Mackay Andrew R
Abstract excerpt
Nerve growth factor receptor TrkA is critical for development and maturation of central and peripheral nervous systems, regulating proliferation, differentiation and apoptosis. In cancer, TrkA frequently exhibits suppressor activity in nonmutated form and oncogenic activity upon mutation. Our identification of a novel hypoxia-regulated alternative TrkAIII splice variant, expressed by neural crest-derived...
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