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Article

NTRK gene fusions as novel targets of cancer therapy across multiple tumour types

1 Jan 2016

Abstract excerpt

The tropomyosin receptor kinase (Trk) receptor family comprises 3 transmembrane proteins referred to as Trk A, B and C (TrkA, TrkB and TrkC) receptors that are encoded by the NTRK1, NTRK2 and NTRK3 genes, respectively. These receptor tyrosine kinases are expressed in human neuronal tissue and play an essential role in the physiology of development and function of the nervous system through activation by...

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PMID: 27843590
DOI: 10.1136/esmoopen-2015-000023

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