Alternative TrkAIII Splicing: A Potential Regulated Tumor-Promoting Switch and Therapeutic Target in Neuroblastoma

Abstract excerpt

An association between elevated tyrosine kinase receptor (Trk)-A expression and better prognosis; the absence of mutation-activated TrkA oncogenes; the induction of apoptosis, growth arrest, morphological differentiation and inhibition of xenograft growth; and angiogenesis by TrkA gene transduction, provide the basis for the current concept of an exclusively tumor-suppressor role for TrkA in the aggressive...

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