Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NTRK Fusions in Central Nervous System Tumors: A Rare, but Worthy Target

23 Jan 2020

Abstract excerpt

The neurotrophic tropomyosin receptor kinase (NTRK) genes (NTRK1, NTRK2, and NTRK3) code for three transmembrane high-affinity tyrosine-kinase receptors for nerve growth factors (TRK-A, TRK-B, and TRK-C) which are mainly involved in nervous system development. Loss of function alterations in these genes can lead to nervous system development problems; conversely, activating alterations harbor oncogenic potential,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Glioma Diagnosis and Treatment
Share to Neuroblastoma Research and Treatments
Share to Protein Degradation and Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31979374
DOI: 10.3390/ijms21030753

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NTRK Fusions in Central Nervous System Tumors: A Rare, but Worthy TargetPMID 31979374Read ↗

A review of NTRK fusions in cancerSemantic proximity Read ↗

NTRK gene fusions as novel targets of cancer therapy across multiple tumour typesSemantic proximity Read ↗

Testing algorithm for identification of patients with TRK fusion cancerSemantic proximity Read ↗

Emerging Targeted Therapy for Tumors with NTRK Fusion Proteins.Semantic proximity Read ↗

NTRK-fused central nervous system tumours: clinicopathological and genetic insights and response to TRK inhibitorsSemantic proximity Read ↗

Prevalence of neurotrophic tropomyosin receptor kinase ( NTRK ) fusion gene positivity in patients with solid tumors in JapanSemantic proximity Read ↗

Expert consensus on the diagnosis and treatment of NTRK gene fusion solid tumors in ChinaSemantic proximity Read ↗

Multidisciplinary consensus on optimising the detection of NTRK gene alterations in tumoursSemantic proximity Read ↗

Analysis of NTRK Alterations in Pan-Cancer Adult and Pediatric Malignancies: Implications for NTRK-Targeted TherapeuticsSemantic proximity Read ↗

NTRK gene fusions in solid tumors: agnostic relevance, prevalence and diagnostic strategiesSemantic proximity Read ↗

NTRK Fusions, from the Diagnostic Algorithm to Innovative Treatment in the Era of Precision MedicineSemantic proximity Read ↗

NTRK Fusions in Sarcomas: Diagnostic Challenges and Clinical AspectsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.