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Article

Clinical significance of <i>NTRK</i> family gene expression in neuroblastomas

11 Oct 2011

Abstract excerpt

BACKGROUND: Neuroblastomas (NBs) are characterized by clinical heterogeneity, from spontaneous regression to relentless progression. The pattern of NTRK family gene expression contributes to these disparate behaviors. TrkA/NTRK1 is expressed in favorable NBs that regress or differentiate, whereas TrkB/NTRK2 and its ligand brain-derived neurotrophic factor (BDNF) are co-expressed in unfavorable NBs, representing...

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PMID: 21990266
DOI: 10.1002/pbc.23343

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