Article

Neoadjuvant PD-1 blockade induces T cell and cDC1 activation but fails to overcome the immunosuppressive tumor associated macrophages in recurrent glioblastoma

2021-08-13

Abstract excerpt

<title>Abstract</title> <p>Primary brain tumors, such as glioblastoma (GBM), have been remarkably resistant to immunotherapy, even though pre-clinical models suggest effectiveness. To understand this better in patients, we took advantage of our recent neoadjuvant treatment paradigm to map the infiltrating immune cell landscape of GBM and how this is altered following PD-1 checkpoint blockade using high dimensiona...

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Literature Corpus work: ed3d0f03-f003-5d65-9d70-fe8727749716
DOI: 10.21203/rs.3.rs-793187/v1

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