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Single-cell analysis of CX3CR1 <sup>+</sup> cells reveal a pathogenic role for BIRC5 <sup>+</sup> myeloid proliferating cells driven by <i>Staphylococcus aureus</i> leukotoxins

2023-02-27

Abstract excerpt

Our previous studies identified a population of stem cell-like proliferating myeloid cells within inflamed tissues that could serve as a reservoir for tissue macrophages to adopt different activation states depending on the microenvironment. By lineage tracing cells derived from CX3CR1 + precursors in mice during infection and profiling by scRNA-seq, here we identify a cluster of BIRC5 + myeloid cells that expan...

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Literature Corpus work
ed3c44c1-9046-5f51-b547-5dc309fe21d0
DOI
10.1101/2023.02.27.529760
Open publication

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Single-cell analysis of CX3CR1 <sup>+</sup> cells reveal a pathogenic role for BIRC5 <sup>+</sup> myeloid proliferating cells driven by <i>Staphylococcus aureus</i> leukotoxinsDOI 10.1101/2023.02.27.529760
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