Article

Programmed genome editing of the omega-1 ribonuclease 1 of the blood fluke, <i>Schistosoma mansoni</i>

2018-07-02

Abstract excerpt

CRISPR/Cas9 based genome editing has yet been reported in parasitic or indeed any species of the phylum Platyhelminthes. We tested this approach by targeting omega-1 (ω1) of Schistosoma mansoni as a proof of principle. This secreted ribonuclease is crucial for Th2 priming and granuloma formation, providing informative immuno-pathological readouts for programmed genome editing. Schistosome eggs were either exposed...

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Literature Corpus work: 1664da7d-597f-51f7-8650-6b34f8f9a026
DOI: 10.1101/358424

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