Article

IRF4 is a master regulator of multinucleated giant cell formation

2025-11-04

Abstract excerpt

Multinucleated giant cells (MGCs) are a hallmark pathological feature of a wide range of diseases, yet the mechanisms underlying their formation and function remain poorly understood. Although it is recognized that MGCs arise from a heterogeneous pool of myeloid precursors, how a committed MGC fate develops therein remains unknown. Here, combining temporal in vitro and in vivo differentiation of bone marrow-deri...

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Literature Corpus work: 674a8d63-45ea-5f85-a77d-6ba72ffc2876
DOI: 10.1101/2025.11.03.686191

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