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Article

Novel CD11b+Gr-1+Sca-1+ myeloid cells drive mortality in bacterial infection.

Science advances - 1 Jan 2020

Park Min Young, Kim Hyung Sik, Lee Ha Young, Zabel Brian A, Bae Yoe-Sik

Abstract excerpt

Extreme pathophysiological stressors induce expansion of otherwise infrequent leukocyte populations. Here, we found a previously unidentified CD11b+Gr-1+ myeloid cell population that expresses stem cell antigen-1 (Sca-1) induced upon experimental infection with Staphylococcus aureus. Although CD11b+Gr-1+Sca-1+ cells have impaired migratory capacity and superoxide anion-producing activity, they secrete increased...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32010784
DOI: 10.1126/sciadv.aax8820
PMCID: PMC6976299

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