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Article

α-Toxin Regulates Local Granulocyte Expansion from Hematopoietic Stem and Progenitor Cells in Staphylococcus aureus-Infected Wounds.

Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2017

Falahee Patrick C, Anderson Leif S, Reynolds Mack B, Pirir Mauricio, McLaughlin Bridget E, Dillen Carly A, Cheung Ambrose L, Miller Lloyd S, Simon Scott I

Abstract excerpt

The immune response to Staphylococcus aureus infection in skin involves the recruitment of polymorphonuclear neutrophils (PMNs) from the bone marrow via the circulation and local granulopoiesis from hematopoietic stem and progenitor cells (HSPCs) that also traffic to infected skin wounds. We focus on regulation of PMN number and function and the role of pore-forming α-toxin (AT), a virulence factor that causes...

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Identifiers

PMID: 28733486
DOI: 10.4049/jimmunol.1700649
PMCID: PMC5568467

Genes

TLR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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