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Article

Interstitial macrophage phenotypes in Schistosoma-induced pulmonary hypertension.

Frontiers in immunology - 1 Jan 2024

Kumar Rahul, Kumar Sushil, Mickael Claudia, Fonseca Balladares Dara, Nolan Kevin, Lee Michael H, Sanders Linda, Nilsson Julia, Molofsky Ari B, Tuder Rubin M, Stenmark Kurt R, Graham Brian B

Abstract excerpt

Background: Schistosomiasis is a common cause of pulmonary hypertension (PH) worldwide. Type 2 inflammation contributes to the development of Schistosoma-induced PH. Specifically, interstitial macrophages (IMs) derived from monocytes play a pivotal role by producing thrombospondin-1 (TSP-1), which in turn activates TGF-β, thereby driving the pathology of PH. Resident and recruited IM subpopulations have recently...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Receptors, CCR2

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Source

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Identifiers

PMID: 38779688
DOI: 10.3389/fimmu.2024.1372957
PMCID: PMC11109442

Genes

CCR2
FOLR2
CCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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