Article

Metabolically-Driven Maturation of hiPSC-Cell Derived Cardiac Chip

2018-12-07

Abstract excerpt

Human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CM) are a promising in vitro tool for drug development and disease modeling, but their immature electrophysiology limits diagnostic utility. Tissue engineering approaches involving aligned 3D cultures enhance hiPSC-CM structural maturation but are insufficient to induce mature electrophysiology. We hypothesized that mimicking post-natal switching o...

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Literature Corpus work: 7daa596b-50ae-52c1-9e1a-93a13c8c225a
DOI: 10.1101/485169

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