Small molecule inhibitors of <i>trans</i> -translation have broad-spectrum antibiotic activity

Abstract excerpt

The trans-translation pathway for protein tagging and ribosome release plays a critical role for viability and virulence in a wide range of pathogens but is not found in animals. To explore the use of trans-translation as a target for antibiotic development, a high-throughput screen and secondary screening assays were used to identify small molecule inhibitors of the pathway. Compounds that inhibited protein...

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• Share to Bacteriophages and microbial interactions
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