Article
Mycobacterial HflX is a ribosome splitting factor that mediates antibiotic resistance.
Proceedings of the National Academy of Sciences of the United States of America - 7 Jan 2020
Rudra Paulami, Hurst-Hess Kelley R, Cotten Katherine L, Partida-Miranda Andrea, Ghosh Pallavi
Abstract excerpt
Antibiotic resistance in bacteria is typically conferred by proteins that function as efflux pumps or enzymes that modify either the drug or the antibiotic target. Here we report an unusual mechanism of resistance to macrolide-lincosamide antibiotics mediated by mycobacterial HflX, a conserved ribosome-associated GTPase. We show that deletion of the hflX gene in the pathogenic Mycobacterium abscessus, as well as...
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