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Article

Novel rapidly diversifiable antimicrobial RNA polymerase switch region inhibitors with confirmed mode of action in Haemophilus influenzae.

Journal of bacteriology - 1 Oct 2012

Buurman Ed T, Foulk Melinda A, Gao Ning, Laganas Valerie A, McKinney David C, Moustakas Demetri T, Rose Jonathan A, Shapiro Adam B, Fleming Paul R

Abstract excerpt

A series of inhibitors with a squaramide core was synthesized following its discovery in a high-throughput screen for novel inhibitors of a transcription-coupled translation assay using Escherichia coli S30 extracts. The inhibitors were inactive when the plasmid substrate was replaced with mRNA,...

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Source

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Identifiers

PMID: 22843845
DOI: 10.1128/JB.01103-12
PMCID: PMC3458661

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22843845-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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