Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Novel rapidly diversifiable antimicrobial RNA polymerase switch region inhibitors with confirmed mode of action in Haemophilus influenzae.

Journal of bacteriology - 1 Oct 2012

Buurman Ed T, Foulk Melinda A, Gao Ning, Laganas Valerie A, McKinney David C, Moustakas Demetri T, Rose Jonathan A, Shapiro Adam B, Fleming Paul R

Abstract excerpt

A series of inhibitors with a squaramide core was synthesized following its discovery in a high-throughput screen for novel inhibitors of a transcription-coupled translation assay using Escherichia coli S30 extracts. The inhibitors were inactive when the plasmid substrate was replaced with mRNA, suggesting they interfered with transcription. This was confirmed by their inhibition of purified E. coli RNA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA-Directed RNA Polymerases
Share to Drug Evaluation, Preclinical

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drug Resistance, Bacterial

Share to Enzyme Inhibitors

Share to Haemophilus influenzae

Share to High-Throughput Screening Assays

Share to Mutant Proteins

Share to Rifampin

Source

Open in PubMed Open full text

Identifiers

PMID: 22843845
DOI: 10.1128/JB.01103-12
PMCID: PMC3458661

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Novel rapidly diversifiable antimicrobial RNA polymerase switch region inhibitors with confirmed mode of action in Haemophilus influenzae.PMID 22843845Read ↗

Evaluating the activity of the RNA polymerase inhibitor myxopyronin B against Staphylococcus aureus.Semantic proximity Read ↗

A small molecule that inhibits the evolution of antibiotic resistanceSemantic proximity Read ↗

A Synthetic Antibiotic Scaffold Effective Against Multidrug-Resistant Bacterial PathogensSemantic proximity Read ↗

Antibiotics GE23077, Novel Inhibitors of Bacterial RNA Polymerase I. Taxonomy, Isolation and CharacterizationSemantic proximity Read ↗

Novel Chemical Scaffolds for Inhibition of Rifamycin-Resistant RNA Polymerase Discovered from High-Throughput Screening.Semantic proximity Read ↗

Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanismSemantic proximity Read ↗

A Natural Depsipeptide Antibiotic that Targets the E site of the Bacterial RibosomeSemantic proximity Read ↗

Inhibition of RNA Polymerase by Rifampicin and Rifamycin-Like MoleculesSemantic proximity Read ↗

In vitro evaluation of CBR-2092, a novel rifamycin-quinolone hybrid antibiotic: studies of the mode of action in Staphylococcus aureus.Semantic proximity Read ↗

Synthetic macrolides overcoming MLSBK-resistant pathogensSemantic proximity Read ↗

Cyclic lipopeptide natural products as taxa-specific antibacterial inhibitors of the lipid II flippaseSemantic proximity Read ↗

A Broad Spectrum Lasso Peptide Antibiotic Targeting the Bacterial RibosomeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.