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Article

RacGAP1-driven focal adhesion formation promotes melanoma transendothelial migration through mediating adherens junction disassembly.

Biochemical and biophysical research communications - 27 Mar 2015

Zhang Pu, Bai Huiyuan, Fu Changliang, Chen Feng, Zeng Panying, Wu Chengxiang, Ye Qichao, Dong Cheng, Song Yang, Song Erqun

Abstract excerpt

Melanoma cell migration across vascular endothelial cells is an essential step of tumor metastasis. Here, we provide evidence that RacGAP1, a cytokinesis-related Rho GTPase-activating protein, contributed to this process. Depletion of RacGAP1 with RacGAP1-targeting siRNA or overexpression of RacGAP1 mutant (T249A) attenuated melanoma cell transendothelial migration and concomitant changes of adherens junctions....

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Identifiers

PMID: 25475728
DOI: 10.1016/j.bbrc.2014.11.088

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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