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Article

YAP/TAZ Activation Drives Uveal Melanoma Initiation and Progression.

Cell reports - 3 Dec 2019

Li Huapeng, Li Qi, Dang Kyvan, Ma Shan, Cotton Jennifer L, Yang Sun, Zhu Lihua J, Deng April C, Ip Y Tony, Johnson Randy L, Wu Xu, Punzo Claudio, Mao Junhao

Abstract excerpt

Uveal melanoma (UM), the most common ocular malignancy, is characterized by GNAQ/11 mutations. Hippo/YAP and Ras/mitogen-activated protein kinase (MAPK) emerge as two important signaling pathways downstream of G protein alpha subunits of the Q class (GαQ/11)-mediated transformation, although whether and how they contribute to UM genesis in vivo remain unclear. Here, we adapt an adeno-associated virus (AAV)-based...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 31801083
DOI: 10.1016/j.celrep.2019.03.021
PMCID: PMC7871510

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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