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Article

Uveal melanoma cell lines Mel270 and 92.1 exhibit a mesenchymal phenotype and sensitivity to the cytostatic effects of transforming growth factor beta in vitro.

Molecular vision - 1 Jan 2024

Doudnikoff Coralie, Leclerc Delphine, Angenard Gaëlle, Gilot David, Coulouarn Cédric, Mouriaux Frederic

Abstract excerpt

Purpose: Uveal melanoma (UM) is a deadly cancer with limited therapeutic options. At advanced stages, UM cells metastasize almost exclusively into the liver, where targeting metastatic UM cells remain a clinical challenge. Transforming growth factor beta (TGF-β) exhibits a functional duality in cancer, with one arm limiting tumor growth at an early stage and the second arm promoting metastasis at an advanced...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38601020
PMCID: PMC11006005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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