Article

Reproductive aging causes precocious ZGA and morula gene expression and chromatin hyper-activation in rhesus monkey embryos via maternal SETDB1 insufficiency

2026-06-09

Abstract excerpt

<title>Abstract</title> <p> Maternal aging impairs embryo development. However, little is known regarding the molecular defects in aged human embryos. Combining single-cell RNA sequencing and ATAC-seq, we investigated aging-associated changes in the transcriptome and chromatin accessibility in fully grown GV oocytes, mature eggs, 4C, 8C, and morula embryos from young, middle-aged and old rhesus monkeys. We revea...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ed179cfe-2897-54e9-ba75-cdbf1d50c873
DOI: 10.21203/rs.3.rs-7771199/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Reproductive aging causes precocious ZGA and morula gene expression and chromatin hyper-activation in rhesus monkey embryos via maternal SETDB1 insufficiencyDOI 10.21203/rs.3.rs-7771199/v1Read

Single‐oocyte transcriptome analysis reveals aging‐associated effects influenced by life stage and calorie restrictionSemantic proximity Read

Maternal mRNA deadenylation is defective in <i>in vitro</i> matured mouse and human oocytesSemantic proximity Read

Single human oocyte transcriptome analysis reveals distinct maturation stage‐dependent pathways impacted by ageSemantic proximity Read

Maternal mRNA deadenylation is defective in in vitro matured mouse and human oocytesSemantic proximity Read

Gene expression profiles of single human mature oocytes in relation to ageSemantic proximity Read

Delay in maternal transcript degradation in ovine embryos derived from low competence oocytesSemantic proximity Read

Maternal control of early embryogenesis in mammalsSemantic proximity Read

Dynamic mRNA degradome analyses indicate a role of histone H3K4 trimethylation in association with meiosis-coupled mRNA decay in oocyte agingSemantic proximity Read

Postovulatory aging affects dynamics of mRNA, expression and localization of maternal effect proteins, spindle integrity and pericentromeric proteins in mouse oocytesSemantic proximity Read

Integrated analyses of the single-cell ATAC-seq and RNA-seq reveal the epigenetic landscape of human ovarian agingSemantic proximity Read

Age-Specific Gene Expression Profiles of Rhesus Monkey Ovaries Detected by Microarray AnalysisSemantic proximity Read

MicroRNAs Are Stored in Human MII Oocyte and Their Expression Profile Changes in Reproductive AgingSemantic proximity Read