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Single human oocyte transcriptome analysis reveals distinct maturation stage‐dependent pathways impacted by age

28 Apr 2021

Abstract excerpt

Female fertility is inversely correlated with maternal age due to a depletion of the oocyte pool and a reduction in oocyte developmental competence. Few studies have addressed the effect of maternal age on the human mature oocyte (MII) transcriptome, which is established during oocyte growth and maturation, however, the pathways involved remain unclear. Here, we characterize and compare the transcriptomes of a...

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PMID: 33908703
DOI: 10.1111/acel.13360

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