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Maternal mRNA deadenylation is defective in in vitro matured mouse and human oocytes

2 Jul 2024

Abstract excerpt

Oocyte in vitro maturation is a technique in assisted reproductive technology. Thousands of genes show abnormally high expression in in vitro maturated metaphase II (MII) oocytes compared to those matured in vivo in bovines, mice, and humans. The mechanisms underlying this phenomenon are poorly understood. Here, we use poly(A) inclusive RNA isoform sequencing (PAIso-seq) for profiling the transcriptome-wide...

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PMID: 38956014
DOI: 10.1038/s41467-024-49695-y

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